Description

Boc-D-Threo-3-(Benzo[1,3]Dioxol-5-Yl)Serine CAS NO 1134768-34-5 is a high-purity, non-natural amino acid derivative featuring a protected serine side chain with a benzodioxole moiety. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D and process chemistry teams in the development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a modified serine residue with enhanced stability or specific binding properties.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and metabolic stability.
• Bioconjugation & Probe Development: The reactive functional groups allow for its use in creating labeled peptides or affinity probes for biochemical assays.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for candidate drugs during clinical trial material manufacturing.

Basic Information

Product Name	Boc-D-Threo-3-(Benzo[1,3]Dioxol-5-Yl)Serine
CAS No.	1134768-34-5
Molecular Formula	C15H19NO7
Molecular Weight	325.32 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-D-threo-3-(1,3-benzodioxol-5-yl)serine; Boc-D-3-(3,4-Methylenedioxyphenyl)serine(threo); tert-Butyl ((2R,3S)-3-(benzo[d][1,3]dioxol-5-yl)-2-hydroxy-3-((tert-butoxycarbonyl)amino)propanoate) (common precursor/related name); D-Threo-Boc-Ser(Bzl(3,4-OCH2O))-OH; Boc-D-Ser(3,4-Methylenedioxybenzyl)-OH (threo); (2R,3S)-2-[(tert-Butoxycarbonyl)amino]-3-hydroxy-3-(1,3-benzodioxol-5-yl)propanoic acid; Boc-D-threo-β-Hydroxy-3,4-methylenedioxyphenylalanine
EINECS	Contact for details

Quality Control

Our Boc-D-Threo-3-(Benzo[1,3]Dioxol-5-Yl)Serine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (D-threo isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.