Description

Budesonide-D6 is a deuterated analog of the potent glucocorticoid Budesonide, specifically labeled with six deuterium atoms. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Budesonide in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and drug metabolism research to ensure accurate and reliable data.

Application

• Internal Standard for Bioanalysis: Critical for the accurate quantification of Budesonide in plasma, serum, and urine samples via mass spectrometry.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity Profiling: Used as a reference standard in the identification and quantification of process-related impurities or degradants.
• Regulatory Submissions: Supports method development and validation for studies submitted to regulatory bodies like the FDA and EMA.
• Forensic and Anti-Doping Analysis: Assists in the detection and confirmation of Budesonide in forensic toxicology and sports doping control.

Basic Information

Product Name	Budesonide-D6
CAS No.	1134189-63-1
Molecular Formula	C25H28D6O6
Molecular Weight	434.56 g/mol
Synonyms	Budesonide-d6; 16α,17α-Butylidenebis(oxy)-11β,21-dihydroxy-1,4-pregnadiene-3,20-dione-d6; (11β,16α)-16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione-d6; Deuterated Budesonide; Budesonide (hexadeuterated); Budesonide Internal Standard
EINECS	Contact for details

Quality Control

Our Budesonide-D6 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, purity (by HPLC), isotopic purity (by MS), and residual solvents. We adhere to relevant industry standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.