Description

Ramelteon-D5 CAS NO 1134159-63-9 is a deuterated analog of the selective melatonin receptor agonist Ramelteon, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is critical for ensuring the accuracy and reliability of quantitative analyses, particularly in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control units requiring precise and validated analytical methods.

Application

• Primary use as an Internal Standard for the quantification of Ramelteon via LC-MS/MS and GC-MS.
• Method development and validation in bioanalytical studies for drug metabolism and pharmacokinetics (DMPK).
• Quality control and assurance testing of Ramelteon in active pharmaceutical ingredient (API) and finished dosage form manufacturing.
• Use in clinical research for the precise measurement of Ramelteon plasma concentrations.
• Supporting regulatory submissions to agencies like the FDA and EMA by providing validated analytical data.
• Application in forensic and anti-doping analysis for accurate substance identification and quantification.

Basic Information

Product Name	Ramelteon-D5
CAS No.	1134159-63-9
Molecular Formula	C16H16D5NO2
Molecular Weight	263.38 g/mol
Synonyms	Ramelteon-d5; (S)-N-[2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethyl]propionamide-d5; TAK-375-d5; Rozerem-d5; Deuterated Ramelteon; Ramelteon Internal Standard; Ramelteon Isotopic Label
EINECS	Contact for details

Quality Control

Every batch of Ramelteon-D5 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC, NMR, and MS to confirm identity, potency, and deuterium enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. Our production adheres to cGMP principles suitable for pharmaceutical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.