Description

(R)-Etodolac-D4 is a high-purity, deuterium-labeled stereoisomer of the nonsteroidal anti-inflammatory drug (NSAID) Etodolac. This stable isotope-labeled compound is essential as an internal standard for the precise and accurate quantification of (R)-Etodolac in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical material for pharmaceutical R&D, bioanalytical method development, and clinical pharmacokinetic studies, ensuring data integrity and regulatory compliance.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard for the quantitative analysis of (R)-Etodolac in plasma, serum, and other biological samples via mass spectrometry.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of the absorption, distribution, metabolism, and excretion (ADME) of the active enantiomer in preclinical and clinical research.
• Method Development & Validation: Serves as a critical reference material for developing, optimizing, and validating robust LC-MS/MS methods in compliance with FDA, EMA, and ICH guidelines.
• Pharmaceutical Quality Control: Used in enantiomeric purity testing and impurity profiling of chiral drug substances and finished products.
• Stable Isotope Tracing: Facilitates mechanistic studies in drug metabolism research due to its isotopic label.

Basic Information

Product Name	(R)-Etodolac-D4
CAS No.	1134124-17-6
Molecular Formula	C17H17D4NO3
Molecular Weight	291.37 g/mol (approx.)
Synonyms	(R)-1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic-d4 acid; (R)-Etodolac-d4; (+)-(R)-Etodolac-D4; Deuterated (R)-Etodolac; (R)-Etodolac (tetradeuterated); (R)-Etodolac Internal Standard; (R)-1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic-2,2,3,3-d4 acid
EINECS	Contact for details

Quality Control

Every batch of (R)-Etodolac-D4 is manufactured and analyzed under strict quality management systems. We guarantee high chemical, isotopic, and chiral purity, supported by comprehensive analytical data including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and chiral excess are provided for traceability and to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Isotopic Enrichment	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.