Description

Modafinil-D5 (Mixture Of Diastereomers) is a deuterated isotopologue of the pharmaceutical agent modafinil, specifically designed for use as an internal standard in analytical chemistry. This compound is critical for ensuring the accuracy and reliability of quantitative analyses, such as mass spectrometry, by correcting for variations in sample preparation and instrument response. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments requiring precise measurement of modafinil and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a stable, non-interfering reference compound for the accurate quantification of modafinil in biological matrices (plasma, serum, urine) during pharmacokinetic and bioequivalence studies.
• Pharmaceutical Research & Development: Used in method development and validation for drug metabolism and pharmacokinetics (DMPK) studies to track the parent drug and its metabolic pathways.
• Forensic and Clinical Toxicology: Enables precise measurement of modafinil levels in forensic analysis and therapeutic drug monitoring (TDM) programs.
• Reference Material for Quality Control: Serves as a certified reference material (CRM) for calibrating analytical instruments and verifying the purity of modafinil active pharmaceutical ingredient (API) batches.
• Metabolite Studies: Facilitates the identification and quantification of deuterated metabolites in complex biological samples.

Basic Information

Product Name	Modafinil-D5 (Mixture Of Diastereomers)
CAS No.	1133712-38-5
Molecular Formula	C15H10D5NO2S
Molecular Weight	279.39 g/mol
Synonyms	2-[(Diphenyl-D5-methyl)sulfinyl]acetamide; (RS)-2-[(Diphenyl-D5-methyl)sulfinyl]acetamide; Modafinil-d5; Modafinil (phenyl-D5); Modiodal-d5; Provigil-d5; Alertec-d5; CRL-40940-d5
EINECS	Contact for details

Quality Control

Every batch of Modafinil-D5 (Mixture Of Diastereomers) is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data including NMR (1H, 13C) for structural confirmation and HPLC for purity assessment to ensure isotopic enrichment and chemical purity meet the exacting standards required for analytical applications. A detailed Certificate of Analysis (COA) with lot-specific data is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.