Description

Posaconazole-D4 is a deuterated analog of the potent antifungal agent Posaconazole, specifically designed for use as an internal standard in analytical chemistry. This high-purity, isotopically labeled compound is essential for ensuring accurate quantification and reliable results in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, pharmacokinetic (DMPK) studies, and bioanalytical method development.

Application

• As a stable isotope-labeled internal standard for the precise quantification of Posaconazole in biological samples (e.g., plasma, serum, tissue) using Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• For conducting high-accuracy drug metabolism and pharmacokinetic (DMPK) studies in pharmaceutical research and development.
• In the development and validation of robust bioanalytical methods to meet regulatory standards (e.g., FDA, EMA).
• To correct for matrix effects and instrument variability, thereby improving the reliability and reproducibility of analytical data.
• Use in clinical research for therapeutic drug monitoring (TDM) of Posaconazole in patient samples.
• Supporting forensic and anti-doping analysis where precise measurement of antifungal agents is required.

Basic Information

Product Name	Posaconazole-D4
CAS No.	1133712-26-1
Molecular Formula	C37H38F2D4N8O4
Molecular Weight	700.79 g/mol (for C37H38F2D4N8O4)
Synonyms	Posaconazole-d4; Deuterated Posaconazole; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(2S,3S)-2-hydroxypentyl-3,4,4,4-d4]-3-[(2R,3R)-2-hydroxy-3-pentyl-3,4,4,4-d4]-4H-1,2,4-triazol-3-one; SCH 56592-d4; Noxafil-d4
EINECS	Contact for details

Quality Control

Every batch of Posaconazole-D4 is manufactured and tested under strict quality systems to ensure the highest standards of purity and isotopic enrichment required for analytical applications. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to confirm chemical and isotopic purity. A detailed Certificate of Analysis (COA) is provided with each shipment, containing batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (Deuterium Content)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.