Description

Bortezomib-D5 is a deuterated analog of the proteasome inhibitor Bortezomib, specifically labeled with five deuterium atoms at key molecular positions. This stable isotope-labeled compound is an essential internal standard for the precise quantification of Bortezomib in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development to ensure data accuracy and regulatory compliance.

Application

• Bioanalytical Method Development: Serves as a critical internal standard for the development and validation of sensitive and specific LC-MS/MS assays for Bortezomib quantification.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables accurate measurement of drug concentration in plasma, serum, and tissue samples over time, supporting ADME (Absorption, Distribution, Metabolism, Excretion) profiling.
• Drug Metabolism Research: Used in metabolite identification and profiling studies to track the parent drug without interference from endogenous compounds.
• Clinical Trial Support: Provides reliable quantification in patient samples during clinical phases, ensuring data integrity for regulatory submissions to agencies like the FDA and EMA.
• Quality Control in Manufacturing: Can be utilized in analytical laboratories for method verification and as a reference standard in quality control protocols.

Basic Information

Product Name	Bortezomib-D5
CAS No.	1133706-15-6
Molecular Formula	C19H20D5BN4O4
Molecular Weight	387.26 g/mol (approximate)
Synonyms	[(1R)-3-Methyl-1-[[(2S)-3-phenyl-2-[(pyrazinylcarbonyl)amino]propanoyl]amino]butyl]boronic Acid-d5; Bortezomib (phenyl-d5); MLN-341-d5; PS-341-d5; LDP-341-d5; Velcade-d5 (deuterated); Deuterated Bortezomib Internal Standard
EINECS	Contact for details

Quality Control

Our Bortezomib-D5 is manufactured under strict quality systems to ensure high chemical and isotopic purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results from NMR (¹H, ¹³C) for structural and isotopic confirmation, HPLC for chemical purity, and LC-MS for isotopic enrichment. We adhere to relevant industry guidelines for reference standards to ensure reliability and traceability in your analytical workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure (¹H, ¹³C)
Isotopic Purity (by LC-MS)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.