Description

(±)-Carvedilol-D4 CAS NO 1133705-56-2 is a deuterated isotopologue of the widely used non-selective β-blocker and α-1 blocker, Carvedilol. This high-purity stable-labeled compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in pharmacokinetic and metabolism studies. It is an essential tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory bodies requiring precise measurement of Carvedilol in complex biological matrices.

Application

• Bioanalytical Method Development & Validation: Primary use as an internal standard for Liquid Chromatography-Mass Spectrometry (LC-MS/MS) analysis of Carvedilol.
• Pharmacokinetic (PK) and Pharmacodynamic (PD) Studies: Enables accurate quantification of Carvedilol and its metabolites in plasma, serum, and tissue samples.
• Drug Metabolism and Disposition (DMPK) Research: Critical for tracing metabolic pathways and studying the absorption, distribution, metabolism, and excretion (ADME) profile.
• Clinical Trial Support: Ensures data integrity and meets regulatory requirements for bioequivalence and therapeutic drug monitoring studies.
• Forensic and Anti-Doping Analysis: Provides a reliable reference for confirmatory testing in specialized analytical contexts.
• Quality Control in Pharmaceutical Manufacturing: Can be used in analytical procedures to monitor process-related impurities or degradation products.

Basic Information

Product Name	(±)-Carvedilol-D4
CAS No.	1133705-56-2
Molecular Formula	C24H22D4N2O4
Molecular Weight	410.52 g/mol (approx.)
Synonyms	Carvedilol-d4; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d4; (±)-[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine-d4; 1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d4; DL-Carvedilol-d4; Carvedilol (phenyl-d4); BM-14190-d4
EINECS	Contact for details

Quality Control

Our (±)-Carvedilol-D4 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and MS, to confirm deuterium incorporation and chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥98% by HPLC), isotopic enrichment (≥98 atom % D), and analytical data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Atom % D)	≥ 98.0%
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.