Description

Levetiracetam-D6 is a deuterium-labeled analog of the widely used antiepileptic drug, levetiracetam, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity stable isotope-labeled compound is essential for ensuring accuracy and reliability in pharmacokinetic studies, bioanalytical method development, and drug metabolism research. It is a critical tool for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers requiring precise and reproducible mass spectrometry (LC-MS/MS) data.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for quantifying levetiracetam levels in biological matrices (plasma, serum, urine) with high precision.
• Pharmacokinetic and Bioequivalence Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust clinical assays for monitoring patient drug concentrations.
• Drug Metabolism and Metabolite Identification: Used in mass spectrometry to distinguish drug-derived metabolites from endogenous compounds.
• Analytical Method Development and Validation: Serves as a critical reference material for establishing specificity, accuracy, and reproducibility of new bioanalytical methods.
• Quality Control in Pharmaceutical Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for the parent drug substance.

Basic Information

Product Name	Levetiracetam-D6
CAS No.	1133229-30-7
Molecular Formula	C8H8D6N2O2
Molecular Weight	176.23 g/mol
Synonyms	(2S)-2-(2-Oxopyrrolidin-1-yl)butanamide-3,3,4,4,5,5-d6; Keppra-D6; UCB L059-D6; (S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide-d6; Levetiracetam (hexadeuterated); Levetiracetam-d6 (major); 1-(2-Amino-2-oxobutyl-d6)-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our Levetiracetam-D6 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D6), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to cGMP guidelines for the production of reference standards, ensuring consistency and reliability for critical analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D6)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.