Description

Levetiracetam-D6 [2,3,3,4,4,4-Bu1Yramide-D6) is a stable isotope-labeled analog of the widely used antiepileptic drug, levetiracetam, where six hydrogen atoms are replaced by deuterium. This compound is essential as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology requiring precise measurement of levetiracetam levels in biological matrices.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in LC-MS/MS and GC-MS methods for the quantification of levetiracetam in plasma, serum, and other biological samples.
• Pharmacokinetic Studies: Enables accurate determination of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Critical for developing and validating assays used to monitor levetiracetam concentrations in patient blood to optimize dosing and ensure therapeutic efficacy.
• Metabolite Identification: Aids in the identification and characterization of levetiracetam metabolites using mass spectrometry.
• Forensic and Clinical Toxicology: Used in confirmatory testing for levetiracetam in cases of overdose, compliance monitoring, or post-mortem analysis.
• Pharmaceutical Quality Control: Supports analytical method development and validation for drug substance and product testing within GMP environments.
• Reference Material for Certified Standards: Serves as a high-purity component in the preparation of certified reference materials (CRMs).

Basic Information

Item	Details
Product Name	Levetiracetam-D6 [2,3,3,4,4,4-Bu1Yramide-D6)
CAS No.	1133229-29-4
Molecular Formula	C8H8D6N2O2
Molecular Weight	176.23 g/mol
Synonyms	Levetiracetam-d6; (2S)-2-(2-Oxopyrrolidin-1-yl)butanamide-3,3,4,4,4-d5,d; Keppra-d6; UCB L059-d6; (S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide-d6; 1-(2-Amino-2-oxo-1-(d5)butyl)-2-pyrrolidinone-d; Deuterated Levetiracetam; Levetiracetam (hexadeuterated)
EINECS	Contact for details

Quality Control

Our Levetiracetam-D6 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and Mass Spectrometry, to confirm identity, chemical purity, and deuterium enrichment. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.