Description

(R)-Cetirizine-D4 Dihydrochloride CAS NO 1133210-23-7 is a high-purity, deuterium-labeled internal standard critical for accurate quantitative analysis in bioanalytical and pharmacokinetic studies. This stable isotope-labeled compound is essential for ensuring precision and reliability in mass spectrometry-based assays, minimizing matrix effects and improving data integrity. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in method development and validation for drug metabolism and bioavailability studies.

Application

• Primary use as an internal standard for the quantification of cetirizine and its metabolites in biological matrices (plasma, serum, urine) via LC-MS/MS.
• Method development and validation for bioequivalence and pharmacokinetic studies in clinical and preclinical research.
• Quality control and assurance in the manufacturing of active pharmaceutical ingredients (APIs) for antihistamine drugs.
• Supporting forensic and toxicological analysis for accurate detection and measurement of cetirizine.
• Use in stable isotope dilution assays to achieve superior accuracy and precision in analytical measurements.
• Research applications in studying the absorption, distribution, metabolism, and excretion (ADME) profile of H1-receptor antagonists.

Basic Information

Product Name	(R)-Cetirizine-D4 Dihydrochloride
CAS No.	1133210-23-7
Molecular Formula	C21H21D4Cl2N2O3
Molecular Weight	424.36 g/mol (for monoisotopic mass)
Synonyms	(R)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid-d4 Dihydrochloride; (R)-Cetirizine-d4 2HCl; Levocetirizine-d4 Dihydrochloride; (R)-Cetirizine (phenyl-d4) Dihydrochloride; Zyrtec-d4 Dihydrochloride; Deuterated Cetirizine Internal Standard; [2H4]-Cetirizine Dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of (R)-Cetirizine-D4 Dihydrochloride is manufactured and analyzed under strict quality management systems. The product undergoes comprehensive testing, including chiral purity verification, isotopic enrichment analysis, and impurity profiling by advanced chromatographic and spectroscopic techniques to ensure it meets the exacting standards required for analytical internal standards. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for purity, isotopic purity, and identity.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chiral Purity (Enantiomeric Excess)	≥ 99.0% (R)-enantiomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.