Description

(-)-2,3-Bis[(2R,5R)-2,5-Dimethylphospholanyl]-1-[3,5-Bis(Trifluoromethyl)Phenyl] -1H-Pyrrole-2,5-Dione, Min. 95% [Catasiummnxylf(R)] is a high-purity, chiral phosphine ligand complex designed for advanced asymmetric catalysis. This compound matters for its exceptional ability to induce high enantioselectivity in critical carbon-carbon and carbon-heteroatom bond-forming reactions, enabling the synthesis of complex, single-enantiomer molecules. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-performance catalysts for creating novel active ingredients and intermediates.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones in pharmaceutical intermediate synthesis.
• Cross-Coupling Reactions: Employed in asymmetric Suzuki-Miyaura, Heck, and other palladium-catalyzed cross-couplings to construct chiral biaryl and other sterically demanding frameworks.
• Hydroformylation: Used in the development of regioselective and enantioselective hydroformylation processes for the production of chiral aldehydes.
• Pharmaceutical Research: Critical for the discovery and process development of new chiral drug candidates, including those for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Applied in the manufacture of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial R&D: A valuable tool for methodology development in academic laboratories and for scaling up asymmetric transformations in industrial settings.

Basic Information

Item	Detail
Product Name	(-)-2,3-Bis[(2R,5R)-2,5-Dimethylphospholanyl]-1-[3,5-Bis(Trifluoromethyl)Phenyl] -1H-Pyrrole-2,5-Dione, Min. 95% [Catasiummnxylf(R)]
CAS No.	1133149-41-3
Molecular Formula	C30H33F6NO2P2
Molecular Weight	615.53 g/mol
Synonyms	Catasiummnxylf(R); (R)-Catasiummnxylf; (-)-2,3-Bis[(2R,5R)-2,5-dimethylphospholano]-1-[3,5-bis(trifluoromethyl)phenyl]-1H-pyrrole-2,5-dione; 1-[3,5-Bis(trifluoromethyl)phenyl]-2,3-bis[(2R,5R)-2,5-dimethyl-1-phospholanyl]-1H-pyrrole-2,5-dione; Chiral Phosphine-Pyrrolidine Ligand; Asymmetric Hydrogenation Ligand Catasiummnxylf(R).
EINECS	Contact for details

Quality Control

Our (-)-2,3-Bis[(2R,5R)-2,5-Dimethylphospholanyl]-1-[3,5-Bis(Trifluoromethyl)Phenyl] -1H-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure identity, purity (Min. 95%), and enantiomeric excess meet stringent specifications. Comprehensive Certificates of Analysis (COA) detailing all test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	Min. 95.0%
Enantiomeric Excess (HPLC)	Min. 99.0% ee
Loss on Drying	Max. 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.