Description

2-(3-Bromo-4-(Trifluoromethoxy)Phenyl)-2,2-Difluoroacetic Acid is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. This compound is critical for researchers and manufacturers seeking to introduce unique steric and electronic properties into target molecules, enabling the development of novel materials and active ingredients. It is primarily utilized in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise molecular architecture.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where the trifluoromethoxy and difluoroacetic acid groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer Modification: Incorporated as a monomer or additive to create specialty polymers with enhanced chemical resistance, lower surface energy, and improved weatherability.
• Ligand & Catalyst Development: Employed in organometallic chemistry to synthesize novel ligands for catalysis, leveraging the bromo substituent for further functionalization.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and the exploration of new chemical entities.

Basic Information

Product Name	2-(3-Bromo-4-(Trifluoromethoxy)Phenyl)-2,2-Difluoroacetic Acid
CAS No.	1133116-05-8
Molecular Formula	C9H4BrF5O3
Molecular Weight	335.03 g/mol
Synonyms	2,2-Difluoro-2-[3-bromo-4-(trifluoromethoxy)phenyl]acetic Acid; α,α-Difluoro-3-bromo-4-(trifluoromethoxy)benzeneacetic Acid; 3-Bromo-4-(trifluoromethoxy)benzene-α,α-difluoroacetic Acid; 2-(3-Bromo-4-(trifluoromethoxyl)phenyl)-2,2-difluoroacetic Acid; (3-Bromo-4-(trifluoromethoxy)phenyl)difluoroacetic Acid; Difluoro(3-bromo-4-(trifluoromethoxy)phenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-(3-Bromo-4-(Trifluoromethoxy)Phenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.