Description

2,2-Difluoro-2-(2-(Trifluoromethoxy)Phenyl)Acetic Acid is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both difluoroacetic acid and trifluoromethoxy phenyl groups, makes it a critical intermediate for introducing fluorine motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in the R&D of next-generation herbicides and fungicides, where the fluorine atoms improve lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for specialty monomers in the development of fluorinated polymers with unique surface properties and chemical resistance.
• Ligand and Catalyst Development: Employed in the synthesis of complex, fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable standard and reagent in academic and industrial labs focused on exploring new C-F bond formation reactions.
• Liquid Crystal & OLED Materials: Potential intermediate for creating fluorinated components in electronic display and lighting materials.

Basic Information

Product Name	2,2-Difluoro-2-(2-(Trifluoromethoxy)Phenyl)Acetic Acid
CAS No.	1133116-03-6
Molecular Formula	C9H5F5O3
Molecular Weight	256.13 g/mol
Synonyms	α,α-Difluoro-2-(trifluoromethoxy)phenylacetic Acid; 2-(Trifluoromethoxy)benzoylfluoride, difluoroacetic acid derivative; [2,2-Difluoro-2-(2-trifluoromethoxy-phenyl)-acetic acid]; 2-(2-(Trifluoromethoxy)phenyl)-2,2-difluoroacetic Acid; Difluoro(2-(trifluoromethoxy)phenyl)acetic Acid; (2-(Trifluoromethoxy)phenyl)difluoroacetic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-2-(2-(Trifluoromethoxy)Phenyl)Acetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.