Description

Atazanavir-D5 is a deuterated internal standard of the antiretroviral drug Atazanavir, specifically designed for use in quantitative mass spectrometry. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of analytical results in pharmacokinetic and bioanalytical studies. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and quality control departments requiring precise drug quantification.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Atazanavir in biological matrices (e.g., plasma, serum) using LC-MS/MS and GC-MS techniques.
• Pharmacokinetic Studies: Enables accurate measurement of drug absorption, distribution, metabolism, and excretion (ADME) profiles in clinical and preclinical research.
• Method Development & Validation: Used as a reference material to develop, optimize, and validate robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Drug Metabolism Research: Facilitates studies on metabolite identification and profiling by providing a stable isotopic tracer.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to ensure the accuracy of potency and impurity assays for Atazanavir drug substances and products.

Basic Information

Product Name	Atazanavir-D5
CAS No.	1132747-14-8
Molecular Formula	C38H47D5N6O7
Molecular Weight	~ 712.9 g/mol
Synonyms	Deuterated Atazanavir; Atazanavir (phenyl-d5); BMS-232632-05 (deuterated); (3S,8S,9S,12S)-3,12-Bis(1,1-dimethylethyl)-8-hydroxy-4,11-dioxo-9-(phenyl-d5)-2,5,6,10,13-pentaazatetradecanedioic Acid Dimethyl Ester; ATV-D5; [Phenyl-d5]-Atazanavir
EINECS	Contact for details

Quality Control

Our Atazanavir-D5 is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including NMR and mass spectrometry for structural confirmation and isotopic purity verification. Purity is determined via HPLC to meet exacting standards for research use. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.