Description

Lamotrigine-D3 (2,3-Dichlorophenyl-D3) is a deuterium-labeled internal standard of the anticonvulsant and mood stabilizer Lamotrigine, specifically designed for use in quantitative analytical methods. This high-purity, isotopically enriched compound is essential for ensuring the accuracy and reliability of mass spectrometry-based analyses in pharmaceutical research and development. It is primarily utilized by analytical chemists and researchers in pharmaceutical companies, contract research organizations (CROs), and regulatory testing laboratories for applications such as pharmacokinetic studies, bioequivalence testing, and drug metabolism research.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of Lamotrigine in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and pre-clinical trials.
• Drug Metabolism and Disposition Research: Used in metabolite identification and profiling studies to understand the biotransformation pathways of Lamotrigine.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust analytical methods for monitoring Lamotrigine concentrations in patient samples to optimize dosing.
• Impurity Profiling and Degradation Studies: Acts as a reference standard in stability-indicating methods to identify and quantify related substances and degradation products.
• Forensic and Toxicology Analysis: Provides a reliable standard for the confirmatory analysis of Lamotrigine in forensic investigations.

Basic Information

Product Name	Lamotrigine-D3 (2,3-Dichlorophenyl-D3)
CAS No.	1132746-94-1
Molecular Formula	C9H4D3Cl2N5
Molecular Weight	259.13 g/mol (approx.)
Synonyms	6-(2,3-Dichlorophenyl-D3)-1,2,4-triazine-3,5-diamine; Lamotrigine-d3; Deuterated Lamotrigine; Lamotrigine Internal Standard; 3,5-Diamino-6-(2,3-dichlorophenyl-D3)-1,2,4-triazine; Lamictal-d3 (labeled analog); Lamotrigine (phenyl-D3)
EINECS	Contact for details

Quality Control

Our Lamotrigine-D3 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Each batch is subjected to rigorous analytical testing, including NMR (1H, 13C), mass spectrometry, and HPLC to confirm identity, chemical purity, and isotopic enrichment (typically ≥98 atom % D). Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee traceability and batch-to-batch consistency, meeting the stringent requirements of GLP and GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95% (by NMR)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.