Description

Ropinirole-D14 Hcl CAS NO 1132746-05-4 is a deuterium-labeled internal standard of the dopamine agonist Ropinirole, essential for precise quantitative analysis in bioanalytical research. This high-purity, isotopically enriched compound is critical for ensuring accuracy and reliability in pharmacokinetic and metabolic studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities specializing in LC-MS/MS method development and validation.

Application

• Internal Standard for LC-MS/MS Analysis: Used as a quantitative reference standard in the bioanalysis of Ropinirole and its metabolites in biological matrices like plasma, serum, and urine.
• Pharmacokinetic (PK) and Bioequivalence Studies: Enables accurate measurement of drug concentration-time profiles for clinical and preclinical research.
• Drug Metabolism and Disposition (DMPK) Research: Facilitates the study of absorption, distribution, metabolism, and excretion (ADME) pathways.
• Method Development and Validation: Serves as a critical component in establishing and verifying robust, GLP-compliant analytical methods.
• Therapeutic Drug Monitoring (TDM): Supports the development of assays for monitoring patient drug levels in clinical settings.
• Impurity Profiling and Characterization: Aids in the identification and quantification of related substances in drug substance and product analysis.

Basic Information

Product Name	Ropinirole-D14 Hcl
CAS No.	1132746-05-4
Molecular Formula	C16H10D14N2O•HCl
Molecular Weight	~ 327.9 g/mol
Synonyms	4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one-d14 Hydrochloride; Ropinirole-d14 Hydrochloride; 4-[2-(Dipropylamino)ethyl]-2(3H)-indolone-d14 HCl; Requip-d14 HCl; SKF-101468-d14 Hydrochloride; Deuterated Ropinirole HCl; Ropinirole (D14) Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Ropinirole-D14 Hcl is manufactured and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical identity. We provide comprehensive Certificates of Analysis (COA) detailing specifications for isotopic enrichment (D-content), chemical purity (by HPLC), and confirmation of structure (by NMR and MS). Our quality commitment supports compliance with GLP and GMP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider storing under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.