Description

Dapoxetine-D7 Hcl CAS NO 1132642-56-8 is a deuterium-labeled internal standard of the selective serotonin reuptake inhibitor (SSRI) dapoxetine, specifically designed for analytical and research applications. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry (MS) and liquid chromatography-mass spectrometry (LC-MS) analyses. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control (QC) departments for method development, validation, and bioanalytical studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of dapoxetine and its metabolites in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in preclinical and clinical research.
• Drug Metabolism Studies: Used in metabolite identification and profiling to understand the biotransformation pathways of dapoxetine.
• Method Development & Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with GLP and ICH guidelines.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to ensure the accuracy of potency and impurity testing for dapoxetine API and finished dosage forms.
• Forensic & Clinical Toxicology: Assists in the accurate detection and quantification of dapoxetine in forensic investigations or therapeutic drug monitoring.

Basic Information

Product Name	Dapoxetine-D7 Hcl
CAS No.	1132642-56-8
Molecular Formula	C21H16D7NO • HCl
Molecular Weight	Approx. 366.9 g/mol
Synonyms	Dapoxetine-d7 Hydrochloride; (S)-Dapoxetine-d7 HCl; N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine-d7 Hydrochloride; LY 210448-d7; Dapoxetine Internal Standard-d7; Priligy-d7 (labeled); 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile-d7 Hydrochloride (Note: This is a common mis-assignment; the correct structure corresponds to dapoxetine).
EINECS	Contact for details

Quality Control

Our Dapoxetine-D7 Hcl is manufactured under strict quality systems to ensure the highest standards of purity and isotopic enrichment, which are critical for its role as an internal standard. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity, NMR and MS for structural and isotopic confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications, including chemical purity (typically ≥98%) and isotopic purity (typically ≥99% atom D), are provided and traceable to a certified reference standard.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.