Description

Dasatinib-D8 is a deuterated isotopologue of the tyrosine kinase inhibitor Dasatinib, where eight hydrogen atoms are replaced with deuterium. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, such as LC-MS/MS, ensuring high accuracy and precision in pharmacokinetic and metabolic studies. It is a critical material for pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug development and therapeutic drug monitoring.

Application

• Primary use as an internal standard for the quantification of Dasatinib in biological matrices via mass spectrometry.
• Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) studies during clinical trials and preclinical research.
• Enables reliable drug metabolism and excretion studies by providing a non-interfering reference signal.
• Supports therapeutic drug monitoring (TDM) assay development and validation for precision medicine.
• Used in impurity profiling and degradation studies to understand drug stability.
• Critical for GLP/GMP-compliant bioanalysis in regulatory submissions to agencies like the FDA and EMA.

Basic Information

Product Name	Dasatinib-D8
CAS No.	1132093-70-9
Molecular Formula	C₂₂H₂₂ClN₇O₂S₂D₈
Molecular Weight	506.10 g/mol (for monoisotopic mass)
Synonyms	Dasatinib-d8; BMS-354825-d8; N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide-d8; Sprycel-d8; Deuterated Dasatinib; Dasatinib (D8)
EINECS	Contact for details

Quality Control

Our Dasatinib-D8 is manufactured under controlled conditions to ensure the highest isotopic and chemical purity required for sensitive analytical applications. Each batch undergoes rigorous quality testing, including HPLC, NMR, and MS analysis, to confirm identity, chemical purity, and isotopic enrichment (typically ≥98% deuterium incorporation). Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to support GMP/GLP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D-enrichment)	≥98 atom % D
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.