Description

Apixaban-D3 is a deuterated isotopologue of the direct Factor Xa inhibitor Apixaban, specifically labeled with three deuterium atoms. This stable isotope-labeled compound is an essential reference standard and internal standard for the precise quantification of Apixaban in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is a critical tool for pharmaceutical research and development, clinical laboratories, and forensic toxicology professionals requiring the highest levels of accuracy and reliability in pharmacokinetic studies, bioequivalence assessments, and therapeutic drug monitoring.

Application

• LC-MS/MS Internal Standard: Primary application as a stable isotope-labeled internal standard for the accurate quantification of Apixaban in plasma, serum, and other biological fluids.
• Pharmacokinetic & Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Serves as a critical component in developing and validating robust, sensitive, and specific analytical methods compliant with FDA, EMA, and ICH guidelines.
• Therapeutic Drug Monitoring (TDM): Used in clinical laboratories to ensure accurate measurement of Apixaban concentrations in patient samples for dose optimization and safety.
• Forensic & Clinical Toxicology: Assists in the definitive identification and quantification of Apixaban in cases of overdose, adverse events, or post-mortem investigations.
• Pharmaceutical Quality Control: Can be employed in impurity profiling and stability studies of Apixaban drug substances and products.

Basic Information

Product Name	Apixaban-D3
CAS No.	1131996-12-7
Molecular Formula	C25H22D3N5O4
Molecular Weight	462.52 g/mol
Synonyms	1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide-d3; Apixaban (methyl-d3); Apixaban-d3 (deuterated); 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5-dihydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide-d3; BMS-562247-d3; Eliquis-d3 (deuterated analog); Deuterated Apixaban; [2H3]-Apixaban
EINECS	Contact for details

Quality Control

Our Apixaban-D3 is manufactured under strict quality systems to ensure the highest chemical purity and isotopic enrichment required for sensitive mass spectrometry applications. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, chemical purity (typically ≥98%), and isotopic purity (typically ≥99% atom D). Certificates of Analysis (COA) detailing all specifications, including chromatographic data and spectral confirmation, are provided and can be tailored to meet specific GMP, ICH, or ISO 17025 requirements for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.