Description

Caspofungin Acetate-D4 CAS NO 1131958-73-0 is a deuterated analog of the antifungal medication Caspofungin Acetate, specifically labeled with four deuterium atoms. This compound serves as a critical internal standard in quantitative bioanalytical methods, ensuring precise and accurate measurement of the parent drug in complex biological matrices. It is an essential tool for pharmaceutical R&D, clinical research, and quality control laboratories focused on pharmacokinetic studies and therapeutic drug monitoring of echinocandin antifungals.

Application

• Bioanalytical Reference Standard: Used as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the quantification of Caspofungin in plasma, serum, and tissue samples.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Method Development & Validation: Critical for developing and validating robust, regulatory-compliant analytical methods in Good Laboratory Practice (GLP) and Good Clinical Practice (GCP) environments.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for drug substance and finished product testing.
• Doping Control & Forensic Analysis: Employed in specialized testing protocols for detecting antifungal agents in biological samples.

Basic Information

Product Name	Caspofungin Acetate-D4
CAS No.	1131958-73-0
Molecular Formula	C52H86D4N10O15 • xC2H4O2
Molecular Weight	Contact for details
Synonyms	Caspofungin-d4 Acetate; (1-((4R,5R)-4,5-Dihydroxy-N2-((4"-(pentyloxy)[1,1':4',1"-terphenyl]-4-yl)carbonyl)-L-ornithine)-5-((3R)-3-hydroxy-L-ornithine)-pneumocandin B0-d4 Acetate; MK-0991-d4 Acetate; Cancidas-d4 (deuterated analog)
EINECS	Contact for details

Quality Control

Our Caspofungin Acetate-D4 is manufactured under strict quality systems to ensure the highest standards of isotopic purity and chemical identity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (HPLC), and identification (NMR, MS). We support compliance with ICH Q2(R1) guidelines for analytical method validation and can supply materials suitable for regulated studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.