Description

α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Fluoro-4-Hydroxybenzeneacetic Acid is a high-purity, non-natural amino acid derivative featuring a protected amino group and a phenolic hydroxyl group. This compound serves as a critical pharmaceutical intermediate and building block for advanced organic synthesis, enabling the development of novel bioactive molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex peptides and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of enzyme inhibitors targeting specific proteases due to its unique fluorinated and hydroxylated benzeneacetic acid structure.
• Peptidomimetic Synthesis: Essential for creating peptidomimetics, which are molecules that mimic peptides but with enhanced stability and bioavailability.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation herbicides and pesticides with specific activity.
• Bioconjugation Chemistry: The protected amino and carboxylic acid groups make it suitable for site-specific bioconjugation in antibody-drug conjugate (ADC) development.
• Chemical Biology Probes: Used to create labeled probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis projects and contract research organizations (CROs).

Basic Information

Product Name	α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Fluoro-4-Hydroxybenzeneacetic Acid
CAS No.	1131872-19-9
Molecular Formula	C13H16FNO5
Molecular Weight	285.27 g/mol
Synonyms	2-[[(tert-Butoxycarbonyl)amino]-2-(2-fluoro-4-hydroxyphenyl)acetic acid; Boc-2-Fluoro-4-hydroxy-DL-phenylglycine; N-Boc-2-fluoro-4-hydroxyphenylglycine; (2-Fluoro-4-hydroxyphenyl)((tert-butoxycarbonyl)amino)acetic acid; N-(tert-Butoxycarbonyl)-2-fluoro-4-hydroxyphenylglycine; α-((tert-Butoxycarbonyl)amino)-2-fluoro-4-hydroxybenzeneacetic acid; Boc-F(4-OH)Phg-OH
EINECS	Contact for details

Quality Control

Our α-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-2-Fluoro-4-Hydroxybenzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.