Description

(R)-1,1,1-Trifluoro-2-Butylamine is a high-value chiral building block featuring a trifluoromethyl group and a primary amine functionality. This compound is critical for introducing fluorine atoms and stereochemical complexity into target molecules, enhancing their metabolic stability and binding affinity. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of advanced intermediates, active pharmaceutical ingredients (APIs), and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of fluorinated APIs, particularly in oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel, fluorinated pesticides and herbicides to improve efficacy and environmental profile.
• Asymmetric Catalysis: Serves as a ligand precursor or a chiral auxiliary in catalytic asymmetric synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced materials where fluorine incorporation modifies surface properties.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation and chiral amine chemistry.

Basic Information

Product Name	(R)-1,1,1-Trifluoro-2-Butylamine
CAS No.	1131737-02-4
Molecular Formula	C4H8F3N
Molecular Weight	127.11 g/mol
Synonyms	(R)-1,1,1-Trifluorobutan-2-amine; (R)-2-Amino-1,1,1-trifluorobutane; (R)-α-Methyl-3,3,3-trifluoropropylamine; (2R)-1,1,1-Trifluoro-2-butanamine; (R)-TFBA; (R)-Trifluoro-sec-butylamine; (R)-1,1,1-Trifluoro-sec-butylamine
EINECS	Contact for details

Quality Control

Our (R)-1,1,1-Trifluoro-2-Butylamine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing identity, purity (by GC/HPLC), enantiomeric excess (by Chiral HPLC), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.