Description

1-(2-Bromo-4-(Trifluoromethyl)Phenyl)Ethanone is a high-purity, specialized organic building block featuring both bromo and trifluoromethyl functional groups on an acetophenone core. This compound is valued for its unique reactivity profile, enabling precise molecular construction in advanced chemical synthesis. It is primarily sought by research and development teams and process chemists in the pharmaceutical, agrochemical, and advanced material science sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, herbicides, and fungicides, leveraging the biological activity imparted by the trifluoromethyl group.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, or organic electronic materials that require specific halogenated or fluorinated aromatic units.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Functional Group Transformation: The ketone moiety allows for further derivatization, such as reduction to alcohols or conversion to heterocycles, expanding its utility in chemical libraries.

Basic Information

Product Name	1-(2-Bromo-4-(Trifluoromethyl)Phenyl)Ethanone
CAS No.	1131605-31-6
Molecular Formula	C9H6BrF3O
Molecular Weight	267.05 g/mol
Synonyms	2'-Bromo-4'-(trifluoromethyl)acetophenone; 2-Bromo-4-(trifluoromethyl)acetophenone; 1-[2-Bromo-4-(trifluoromethyl)phenyl]ethan-1-one; Ethanone, 1-[2-bromo-4-(trifluoromethyl)phenyl]-; α-Bromo-α,α,α-trifluoro-m-acetophenone (related); 2-Bromo-α,α,α-trifluoro-4-methylacetophenone (common misnomer)
EINECS	Contact for details

Quality Control

Our production of 1-(2-Bromo-4-(Trifluoromethyl)Phenyl)Ethanone adheres to stringent in-process controls and final batch analysis to ensure high chemical purity and lot-to-lot consistency. Each batch is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.