Description

n-Methyl Naltrexone-D3 Bromide is a high-purity, deuterated derivative of naltrexone, specifically designed for advanced analytical and research applications. This compound serves as a critical internal standard in quantitative mass spectrometry, ensuring precise and reliable measurement of its non-deuterated counterpart in complex biological matrices. It is primarily utilized by pharmaceutical R&D laboratories, clinical research organizations, and forensic toxicology units engaged in pharmacokinetic studies, drug metabolism research, and bioanalytical method development.

Application

• Bioanalytical Reference Standard: Used as a deuterated internal standard in LC-MS/MS and GC-MS for the accurate quantification of naltrexone and its metabolites in plasma, serum, and urine.
• Pharmacokinetic & Metabolism Studies: Essential for tracing drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Forensic Toxicology: Supports confirmatory testing and method validation for opioid antagonist analysis in forensic investigations.
• Pharmaceutical Quality Control: Aids in the impurity profiling and stability testing of naltrexone-based pharmaceutical formulations.
• Research on Opioid Antagonists: Facilitates mechanistic studies on peripheral opioid receptor blockade and related therapeutic pathways.

Basic Information

Product Name	n-Methyl Naltrexone-D3 Bromide
CAS No.	1131456-47-7
Molecular Formula	C21H23D3NO4•Br
Molecular Weight	~452.36 g/mol
Synonyms	Methylnaltrexone-d3 Bromide; N-Methylnaltrexone-d3 Bromide; (R)-N-Methylnaltrexone-d3 Bromide; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinan-7-one-d3 Methobromide; Naltrexone Methyl Bromide-d3; Relistor-d3 (deuterated analog); MNTX-d3 Bromide
EINECS	Contact for details

Quality Control

Every batch of n-Methyl Naltrexone-D3 Bromide is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, verified by advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and deuterium incorporation. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 99.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.