Description

Etoricoxib D4 is a deuterium-labeled stable isotope analog of the selective COX-2 inhibitor etoricoxib, serving as a critical internal standard for precise bioanalytical quantification. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and metabolic studies, where distinguishing the drug from endogenous compounds is paramount. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced drug development and regulatory compliance testing.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative internal standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for the analysis of etoricoxib in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate measurement of drug concentration over time, critical for determining absorption, distribution, metabolism, and excretion (ADME) profiles.
• Metabolite Profiling and Identification: Aids in the detection and structural elucidation of etoricoxib metabolites by providing a stable isotopic reference point.
• Bioequivalence and Clinical Trials: Supports robust analytical method development and validation for clinical studies requiring high precision and reproducibility.
• Method Development and Validation: Serves as a key component in developing and validating GLP/GMP-compliant analytical methods for regulatory submissions.
• Quality Control in Reference Material Production: Can be utilized as a calibrant or system suitability standard in the quality control of non-labeled etoricoxib active pharmaceutical ingredient (API).

Basic Information

Product Name	Etoricoxib D4
CAS No.	1131345-14-6
Molecular Formula	C18H11D4ClN2O2S
Molecular Weight	359.86 g/mol (for D4 isotopologue)
Synonyms	5-Chloro-2-(6-methylpyridin-3-yl)-3-[4-(methylsulfonyl-d3)phenyl-d]pyridine; Etoricoxib-d4; Deuterated Etoricoxib; Etoricoxib (D4); 5-Chloro-6'-methyl-3-[4-(methylsulfonyl-d3)phenyl-d]-2,3'-bipyridine; Arcoxia-d4; MK-0663-d4; L-791456-d4
EINECS	Contact for details

Quality Control

Our Etoricoxib D4 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure the highest standards of isotopic purity and chemical identity. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (chemical and isotopic purity), assay, and impurity profile by HPLC. We adhere to stringent quality protocols suitable for research and development use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity (D-content)	≥98.0 atom % D
Isotopic Enrichment (MS)	D4 ≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.