Description

Iclaprim-D6 is a deuterated internal standard of the antibiotic Iclaprim, essential for ensuring accurate and reliable quantification in analytical methods. This high-purity compound is critical for pharmaceutical research and development, particularly in pharmacokinetic and bioanalytical studies. It is primarily used by analytical laboratories and pharmaceutical manufacturers requiring precise mass spectrometry-based assays.

Application

• Internal standard for the quantitative analysis of Iclaprim in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• Metabolite profiling and drug metabolism studies (ADME) in pharmaceutical R&D.
• Method development and validation for clinical trial sample analysis.
• Quality control and stability testing of Iclaprim drug substances and products.
• Use in forensic and anti-doping analysis for accurate antibiotic detection.
• Supporting regulatory submissions by providing validated analytical data.

Basic Information

Product Name	Iclaprim-D6
CAS No.	1130072-57-9
Molecular Formula	C21H16D6N4O3S
Molecular Weight	404.51 g/mol
Synonyms	Iclaprim-d6; 5-[(2R,4R)-2-Amino-4-methyl-1,2,3,4-tetrahydropyrimidin-1-yl]-3-[4-(cyclopropylamino)-3,5-d6-methylphenyl]thiophene-2-carboxamide; AR-100 d6; RO-48-2622 d6; Deuterated Iclaprim; Iclaprim Internal Standard
EINECS	Contact for details

Quality Control

Our Iclaprim-D6 is manufactured under strict quality control protocols to ensure the highest chemical purity and isotopic enrichment. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (by HPLC), isotopic purity (by MS), and residual solvents. We adhere to cGMP principles for pharmaceutical reference standards to guarantee batch-to-batch consistency and data integrity for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. Due to its hygroscopic nature, the material should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 99.0% D6
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.