Description

4-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Morpholine is a high-value, synthetically versatile boronic ester derivative, serving as a critical advanced pharmaceutical intermediate and building block in modern organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl scaffolds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries who require precise, high-purity intermediates for drug discovery and advanced material fabrication.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aromatic rings, crucial for creating complex molecular architectures in medicinal chemistry.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science & OLED Development: Serves as a precursor for synthesizing organic semiconductors, liquid crystals, and light-emitting materials for electronic devices.
• Chemical Biology & Probe Synthesis: Utilized in creating molecular probes and labeled compounds for biochemical assays and diagnostic applications.
• Academic & Contract Research: A valuable reagent for methodology development and synthetic route exploration in university and CRO laboratories.

Basic Information

Product Name	4-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Morpholine
CAS No.	1129541-03-2
Molecular Formula	C16H23BFNO3
Molecular Weight	307.17 g/mol
Synonyms	4-[3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine; 2-(3-Fluoro-5-morpholin-4-ylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-5-morpholinophenylboronic acid pinacol ester; 4-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)morpholine; Morpholine, 4-[3-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; CAS 1129541-03-2
EINECS	Contact for details

Quality Control

Our production of 4-(3-Fluoro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Morpholine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive applications like pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 19F, 11B), and mass spectrometry. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.