Description

Pemetrexed-D5 Disodium Salt is a deuterated isotopologue of the established chemotherapeutic agent pemetrexed disodium, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical researchers, analytical laboratories, and CROs engaged in the development, validation, and quality control of pemetrexed-based therapies.

Application

• Internal Standard for LC-MS/MS Analysis: Primary application for quantifying pemetrexed levels in biological matrices (plasma, serum, tissue) with enhanced precision.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of absorption, distribution, metabolism, and excretion (ADME) profiles of the parent drug.
• Clinical Research and Therapeutic Drug Monitoring (TDM): Supports method development for monitoring patient drug concentrations to optimize dosing regimens.
• Pharmaceutical Quality Control: Used in analytical method development and validation to ensure the specificity and accuracy of assays for drug substance and product.
• Biomarker and Metabolite Identification: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex samples.
• Regulatory Submissions: Provides the high-quality reference material required for robust bioanalytical data included in FDA, EMA, and other regulatory agency filings.

Basic Information

Product Name	Pemetrexed-D5 Disodium Salt
CAS No.	1129408-57-6
Molecular Formula	C20H14D5N5Na2O6
Molecular Weight	476.38 g/mol (approximate)
Synonyms	Pemetrexed-d5 Disodium; Alimta-d5 Disodium Salt; LY231514-d5 Disodium; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-d5-L-glutamic Acid Disodium Salt; (2S)-2-[[4-[(1RS)-2-(2-Amino-4-oxo-3,4-dihydro-1H-pteridin-6-yl)ethyl]benzoyl]amino]pentanedioic-3,3,4,4,5,5,5-d7 Acid Disodium Salt; Deuterated Pemetrexed Disodium; Pemetrexed (D5) Disodium Salt
EINECS	Contact for details

Quality Control

Our Pemetrexed-D5 Disodium Salt is manufactured under strict quality systems to ensure it meets the exacting requirements for use as a certified reference material. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as isotopic purity, chemical purity, and residual solvent content. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee batch-to-batch consistency and analytical reliability.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity (D5)	≥98.0 atom % D
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.