Description

n-Desmethyl Galanthamine-o-Methyl-D3 is a deuterated derivative of a key galanthamine metabolite, serving as a critical reference standard and analytical tool. This compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies in pharmaceutical research and development. It is primarily required by analytical laboratories, CROs, and pharmaceutical companies engaged in the development and quality control of acetylcholinesterase inhibitors and related neurological therapeutics.

Application

• Pharmaceutical Reference Standard: Used as a certified internal standard for the precise quantification of galanthamine and its metabolites in biological matrices via LC-MS/MS and GC-MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for tracing metabolic pathways, conducting mass balance studies, and determining pharmacokinetic parameters in preclinical and clinical research.
• Bioanalytical Method Development: Enables the development and validation of highly sensitive and specific analytical methods for drug monitoring and impurity profiling.
• Isotope Dilution Mass Spectrometry: Employed in high-precision quantitative analysis to correct for analyte loss and matrix effects, ensuring superior data accuracy.
• Impurity Characterization: Aids in the identification and control of process-related impurities and degradants during the manufacturing of galanthamine-based APIs.
• Regulatory Compliance Testing: Supports testing for regulatory submissions (e.g., FDA, EMA) requiring validated methods with stable isotope-labeled standards.

Basic Information

Product Name	n-Desmethyl Galanthamine-o-Methyl-D3
CAS No.	1128108-98-4
Molecular Formula	C17H18D3NO3
Molecular Weight	290.38 g/mol (approx.)
Synonyms	Galanthamine N-Desmethyl-O-methyl-D3; 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 11-desmethyl-3-O-methyl-D3; O-Methyl-N-desmethylgalanthamine-d3; Deuterated Galanthamine Metabolite Standard; Galanthamine Impurity D3; Lycoramine derivative D3; Stable Isotope-Labeled Galanthamine Analog
EINECS	Contact for details

Quality Control

Every batch of n-Desmethyl Galanthamine-o-Methyl-D3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical purity and isotopic enrichment, supported by comprehensive analytical data including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) specifying purity, isotopic purity (D-content), and chromatographic data is provided with each shipment to ensure it meets the stringent requirements for use as a reference material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.