Description

Donepezil-D5 is a deuterated internal standard of the acetylcholinesterase inhibitor Donepezil, specifically designed for use in quantitative analytical methods. This high-purity reference material is essential for ensuring accuracy and reliability in pharmacokinetic and bioanalytical studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and quality control departments for applications in drug metabolism and mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Serves as a critical deuterated internal standard for the precise quantification of Donepezil in biological matrices (e.g., plasma, serum) using liquid chromatography-tandem mass spectrometry.
• Pharmacokinetic Studies: Enables accurate measurement of drug concentration over time to study absorption, distribution, metabolism, and excretion (ADME) profiles.
• Bioanalytical Method Development & Validation: Used as a reference compound to develop, optimize, and validate robust analytical methods compliant with FDA and ICH guidelines.
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and stability of Donepezil.
• Quality Control & Assurance: Employed in pharmaceutical QC labs to ensure the accuracy of analytical results for drug substance and product testing.
• Clinical Trial Support: Provides reliable data for therapeutic drug monitoring during clinical trials for Alzheimer's disease treatments.

Basic Information

Product Name	Donepezil-D5
CAS No.	1128086-25-8
Molecular Formula	C24H28D5NO3
Molecular Weight	384.55 g/mol (approx.)
Synonyms	Donepezil-d5; Aricept-d5; (±)-2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenyl-d5)-methyl]-4-piperidinyl]methyl]-1H-inden-1-one; E2020-d5; 1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine-d5; 2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone-d5
EINECS	Contact for details

Quality Control

Our Donepezil-D5 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for analytical applications. Each batch undergoes rigorous testing, including chromatographic purity and isotopic abundance analysis, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and spectroscopic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98.0 atom % D
Chemical Purity	≥95.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.