Description

Aztreonam-D6 is a deuterium-labeled isotopologue of the monobactam antibiotic aztreonam, specifically designed for use as an internal standard in quantitative analytical methods. This high-purity reference material is critical for ensuring accuracy and reliability in mass spectrometry-based analyses, where it compensates for variations in sample preparation and instrument response. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities engaged in pharmacokinetic studies, metabolic profiling, and quality control of aztreonam and related compounds.

Application

• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the precise quantification of aztreonam in biological matrices (e.g., plasma, serum, urine) during bioanalytical method development and validation.
• Pharmacokinetic and Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Impurity and Degradation Profiling: Used as a reference compound in analytical methods to identify and quantify impurities or degradation products in pharmaceutical formulations.
• Clinical Diagnostics and Therapeutic Drug Monitoring (TDM): Supports the development of robust assays for measuring aztreonam concentrations in patient samples to optimize dosing regimens.
• Environmental and Food Safety Testing: Applicable in residue analysis methods for detecting trace levels of antibiotics in environmental water samples or food products.

Basic Information

Product Name	Aztreonam-D6
CAS No.	1127452-94-1
Molecular Formula	C13H11D6N5O8S2
Molecular Weight	435.46 g/mol
Synonyms	(2S,3S)-3-(((2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(((2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)vinyl)amino)-2-methyl-4-oxo-1-azetidinesulfonic Acid-d6; Azactam-d6; SQ 26,776-d6; Monobactam-d6; Deuterated Aztreonam; Aztreonam (hexadeuterated); Aztreonam Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Aztreonam-D6 is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for critical research and regulatory submission support. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as isotopic purity, chemical purity, and residual solvent content. Our quality protocols are designed to support compliance with GMP/GLP principles where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a cool, dry place. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference
Purity (HPLC)	≥ 98.0%
Isotopic Purity (by MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.