Description

Olmesartan Medoxomil-D6 is a deuterated analog of the active pharmaceutical ingredient Olmesartan Medoxomil, specifically designed for use as an internal standard in quantitative bioanalytical methods. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolism studies. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities involved in the development and quality control of antihypertensive medications.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of Olmesartan and its metabolites in biological matrices (plasma, serum, urine) during bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Stable Isotope Dilution Assays: Used in mass spectrometry-based assays to correct for matrix effects and instrument variability, improving data integrity.
• Pharmaceutical Quality Control: Supports impurity profiling and assay development for drug substance and finished product testing.
• Reference Standard for Deuterated Compounds: Serves as a certified reference material for calibrating analytical instruments and validating methods.

Basic Information

Product Name	Olmesartan Medoxomil-D6
CAS No.	1127298-67-2
Molecular Formula	C29H24D6N6O6
Molecular Weight	552.62 g/mol
Synonyms	Olmesartan Medoxomil Deuterated; Olmesartan-d6 Medoxomil; (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate-d6; Benicar-d6; CS-866-d6; RN-1127298-67-2
EINECS	Contact for details

Quality Control

Our Olmesartan Medoxomil-D6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity, chemical purity, and isotopic enrichment. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures the material's suitability for demanding regulatory applications in pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Avoid repeated or prolonged exposure to ambient conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.