Description

(±)-Prasugrel-D3 (Acetate-D3) CAS NO 1127253-02-4 is a deuterium-labeled isotopologue of the active metabolite of the antiplatelet drug Prasugrel, specifically labeled on the acetate moiety. This compound is an essential internal standard for the accurate quantification of Prasugrel metabolites in complex biological matrices using advanced analytical techniques. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and clinical trial support.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the precise and accurate quantification of Prasugrel and its metabolites in plasma, serum, and other biological samples during bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK) Research: Used to study the absorption, distribution, metabolism, and excretion (ADME) profile of Prasugrel in preclinical and clinical development.
• Clinical Trial Support: Enables reliable therapeutic drug monitoring and pharmacokinetic profiling in human subjects during clinical phases.
• Bioanalytical Method Development and Validation: Serves as a key reference material for developing, optimizing, and validating robust HPLC and mass spectrometry-based assays.
• Forensic and Anti-Doping Analysis: Potential use in specialized testing protocols where detection and confirmation of drug-related compounds are required.
• Stable Isotope Labeling Studies: Employed in mechanistic studies to trace metabolic pathways and understand biotransformation processes.

Basic Information

Product Name	(±)-Prasugrel-D3 (Acetate-D3)
CAS No.	1127253-02-4
Molecular Formula	C20H17D3FNO3S
Molecular Weight	376.45 g/mol
Synonyms	Prasugrel-d3 (acetate-d3); 5-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl Acetate-d3; Prasugrel Metabolite R-138727-d3; R-138727-d3; (RS)-Prasugrel-D3 Acetate; Deuterated Prasugrel Acetate; Prasugrel Acetate-d3
EINECS	Contact for details

Quality Control

Our (±)-Prasugrel-D3 (Acetate-D3) is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic methods, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and must be handled under inert, dry conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.