Description

Linezolid-D3 is a deuterated internal standard of the oxazolidinone antibiotic linezolid, specifically designed for use in quantitative analytical methods. This high-purity compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses, where it corrects for variations in sample preparation and instrument response. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and forensic toxicology sectors who require precise quantification of linezolid in complex biological matrices.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the accurate quantification of linezolid in plasma, serum, and tissue samples using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise measurement of drug concentration-time profiles in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust assays for monitoring linezolid levels in patient samples to optimize dosing and minimize toxicity.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in metabolism studies.
• Forensic and Anti-Doping Analysis: Used as a reference standard in confirmatory methods for detecting linezolid in forensic investigations or sports doping control.
• Method Development and Validation: Critical for establishing and validating new analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Linezolid-D3
CAS No.	1127120-38-0
Molecular Formula	C16H17D3FN3O4
Molecular Weight	340.35 g/mol
Synonyms	(S)-N-({3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide-d3; Linezolid (methyl-d3); PNU-100766-d3; Zyvox-d3; (S)-N-[[3-[3-Fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide-d3; Deuterated Linezolid; Linezolid Internal Standard
EINECS	Contact for details

Quality Control

Our Linezolid-D3 is manufactured under strict quality control protocols to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, purity, and deuterium incorporation. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.