Description

Fmoc-Val-Bt CAS NO 1126433-37-1 is a specialized, high-purity amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the controlled, sequential assembly of complex peptides, ensuring high coupling efficiency and minimal racemization. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a protected valine derivative for the automated, stepwise construction of custom peptide sequences.
• Pharmaceutical Research: A key intermediate in the development and production of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive compounds and drug candidates.
• Bioconjugation: Facilitates the site-specific labeling or modification of peptides with probes, tags, or other molecules for diagnostic and research applications.
• Academic & Institutional Research: Employed in biochemistry and molecular biology laboratories for studying protein structure, function, and interactions.
• Custom Peptide Service Providers: A fundamental reagent for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Val-Bt
CAS No.	1126433-37-1
Molecular Formula	C21H22N2O3
Molecular Weight	350.42 g/mol
Synonyms	Fmoc-Valine benzotriazole ester; Fmoc-Val-OBt; N-(9-Fluorenylmethoxycarbonyl)-L-valine benzotriazol-1-yl ester; 1-({[(9H-Fluoren-9-yl)methoxy]carbonyl}-L-valyl)-1H-benzotriazole; Fmoc-L-Valine-1-benzotriazolyl ester; Fmoc-Val-Bt ester; Fmoc-Val-OBzt; Fmoc-Val-OBt ester
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Val-Bt is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive peptide synthesis. We provide full traceability and Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles via HPLC, NMR, and MS. Our quality commitment aligns with the needs of cGMP and ISO-certified environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.