Description

4-Chloro-2-Fluoro-5-Methylphenylboronic Acid,Pinacol is a high-purity, synthetically valuable organoboron building block. This compound is essential for Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research for constructing complex biaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex, multi-substituted biphenyl or heterobiaryl scaffolds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the specific halogenated methylphenyl motif is required for bioactivity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and organic semiconductors.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a core structure in metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Useful for synthesizing molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	4-Chloro-2-Fluoro-5-Methylphenylboronic Acid,Pinacol
CAS No.	1126320-27-1
Molecular Formula	C₁₃H₁₇BClFO₂
Molecular Weight	270.53 g/mol
Synonyms	4-Chloro-2-fluoro-5-methylbenzeneboronic acid pinacol ester; (4-Chloro-2-fluoro-5-methylphenyl)boronic acid pinacol ester; 2-(4-Chloro-2-fluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Chloro-2-fluoro-5-methylphenylboronic acid, pinacol ester; Pinacol (4-Chloro-2-fluoro-5-methylphenyl)boronate; Boronic acid, B-(4-chloro-2-fluoro-5-methylphenyl)-, 1,1-dimethylethyl ester; 1126320-27-1 (CAS)
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-5-Methylphenylboronic Acid,Pinacol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.