Description

2-(Oxetan-3-Ylidene)Acetonitrile is a high-value, functionalized nitrile building block featuring a strained oxetane ring, which is pivotal for introducing unique three-dimensionality and polarity into molecular scaffolds. This compound is essential for medicinal chemistry and advanced materials research, enabling the synthesis of novel pharmacophores and polymers with tailored properties. It is primarily sought by pharmaceutical R&D teams, agrochemical innovators, and specialty chemical manufacturers developing next-generation active ingredients and performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex drug candidates, particularly in fragment-based drug discovery and for introducing bioisosteric replacements.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require specific spatial orientation for target binding.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers with enhanced thermal stability, adhesion, or optical properties.
• Ligand & Catalyst Development: Employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for creating activity-based probes and molecular tags due to its reactive nitrile and oxetane functionalities.
• Academic & Industrial R&D: A versatile reagent for exploratory organic synthesis and methodology development in research laboratories.

Basic Information

Product Name	2-(Oxetan-3-Ylidene)Acetonitrile
CAS No.	1123787-67-6
Molecular Formula	C5H5NO
Molecular Weight	95.10 g/mol
Synonyms	3-Oxetanecarbonitrile, 3-methylene-; 3-Methyleneoxetane-3-carbonitrile; 2-(3-Oxetanylidene)acetonitrile; Oxetan-3-ylideneacetonitrile; 3-Cyano-3-methylenexetane; (Oxetan-3-ylidene)acetonitrile; 3-Methyleneoxetane-3-carbonitrile; 1123787-67-6
EINECS	Contact for details

Quality Control

Our 2-(Oxetan-3-Ylidene)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere such as nitrogen or argon when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.