Description

7-(Trifluoromethyl)-3,4-Dihydroquinolin-2(1H)-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core quinolinone scaffold, functionalized with a trifluoromethyl group, makes it a critical intermediate for developing novel pharmaceuticals and agrochemicals. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug discovery programs.
• Agrochemical Research: Used in developing new-generation herbicides, fungicides, and insecticides where the CF3 group imparts desirable lipophilicity and biological activity.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and advanced organic electronic materials.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for fragment-based drug design.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up.

Basic Information

Product Name	7-(Trifluoromethyl)-3,4-Dihydroquinolin-2(1H)-One
CAS No.	1123762-24-2
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinolin-2-one; 2-Oxo-7-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)-2-quinolinone; 7-Trifluoromethyl-3,4-dihydro-2(1H)-quinolinone; 7-Trifluoromethyl-1,2,3,4-tetrahydroquinolin-2-one
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)-3,4-Dihydroquinolin-2(1H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.