Description

Rac o-Desmethyl Naproxen-D3 is a deuterated isotopologue of a key naproxen metabolite, serving as a critical internal standard for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in pharmacokinetic and bioanalytical studies, where distinguishing between endogenous and exogenous compounds is paramount. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers specializing in drug metabolism and bioequivalence testing.

Application

• Bioanalytical Internal Standard: Used as a deuterium-labeled internal standard in LC-MS/MS and GC-MS methods for the quantification of o-desmethyl naproxen in biological matrices (plasma, serum, urine).
• Pharmacokinetic (PK) Studies: Enables accurate tracking of naproxen metabolite levels over time, supporting drug development and regulatory submissions.
• Drug Metabolism and Disposition (DMPK): Facilitates studies on the metabolic pathways and clearance rates of naproxen.
• Forensic and Clinical Toxicology: Assists in the precise identification and measurement of naproxen and its metabolites for diagnostic or legal purposes.
• Method Development and Validation: Critical for developing robust, sensitive, and specific analytical assays in compliance with FDA and ICH guidelines.
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability testing of naproxen-based drug products.

Basic Information

Product Name	Rac o-Desmethyl Naproxen-D3
CAS No.	1122399-99-8
Molecular Formula	C₁₃H₁₁D₃O₃
Molecular Weight	~233.27 g/mol
Synonyms	6-Methoxy-2-naphthylacetic acid-d3 (deuterated metabolite); O-Desmethylnaproxen-D3; 6-Desmethyl Naproxen-D3; (RS)-2-(6-Hydroxy-2-naphthyl)propionic-3,3,3-d3 acid; Naproxen Metabolite D3; DMNP-D3; d3-o-Desmethyl Naproxen; rac-6-O-Desmethylnaproxen-d3
EINECS	Contact for details

Quality Control

Our Rac o-Desmethyl Naproxen-D3 is manufactured under strict quality control protocols to ensure high chemical purity and isotopic enrichment, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic purity (deuterium incorporation), and identity confirmation (by NMR and MS). We adhere to relevant industry standards for reference materials to support your GLP/GMP-compliant research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.