Description

2,3,4-Trifluorophenyl-tert-Butyl-Ether is a high-purity fluorinated aromatic ether building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of pharmaceuticals and agrochemicals, where its unique trifluoromethylphenyl ether structure imparts desirable metabolic stability and lipophilicity to target molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, improving dielectric anisotropy and stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing chemical resistance and surface properties.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to create biaryl structures.
• Organic Synthesis Reagent: Functions as a protected phenol equivalent or a directing group in multi-step synthetic routes in medicinal chemistry.

Basic Information

Item	Details
Product Name	2,3,4-Trifluorophenyl-tert-Butyl-Ether
CAS No.	1121586-34-2
Molecular Formula	C10H11F3O
Molecular Weight	204.19 g/mol
Synonyms	1-tert-Butoxy-2,3,4-trifluorobenzene; 2,3,4-Trifluoro-1-(tert-butoxy)benzene; tert-Butyl 2,3,4-trifluorophenyl ether; (2,3,4-Trifluorophenoxy)-tert-butane; 2,3,4-Trifluorophenyl tert-butyl ether; 2,3,4-Trifluorphenyl-tert-butylether
EINECS	Contact for details

Quality Control

Every batch of 2,3,4-Trifluorophenyl-tert-Butyl-Ether is produced and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency suitable for demanding R&D and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.