Description

L-Glutamic Acid, n-[20-(1,1-Dimethylethoxy)-1,20-Dioxoeicosyl]-, 1-(1,1-Dimethylethyl) Ester is a specialized, high-purity protected amino acid derivative designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise molecular building blocks for peptide synthesis and complex organic transformations. It serves as a key intermediate in pharmaceutical R&D, particularly in the development of novel therapeutic peptides and bioconjugates.

Application

• Pharmaceutical Intermediate: A crucial building block in the solid-phase and solution-phase synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Bioconjugation Chemistry: Used for the site-specific modification of proteins, antibodies, and other biomolecules to create targeted drug delivery systems or diagnostic agents.
• Peptide Research: Enables the introduction of specific glutamic acid residues with protected side chains into custom peptide sequences for structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Serves as a precursor for synthesizing labeled or tagged amino acid derivatives used to study biological processes and enzyme mechanisms.
• Advanced Material Synthesis: Potential use in creating novel peptidomimetics and bio-inspired polymers with tailored properties.

Basic Information

Product Name	L-Glutamic Acid, n-[20-(1,1-Dimethylethoxy)-1,20-Dioxoeicosyl]-, 1-(1,1-Dimethyl) Ester
CAS No.	1119061-70-9
Molecular Formula	C29H53NO6
Molecular Weight	511.74 g/mol
Synonyms	N-[(tert-Butoxy)carbonyl]-L-glutamic acid 1-(1,1-dimethylethyl) 5-[15-(1,1-dimethylethoxy)-1,15-dioxopentadecyl] ester; Boc-Glu(OtBu)-OSu extended chain derivative; L-Glutamic acid, N-[20-(1,1-dimethylethoxy)-1,20-dioxoeicosyl]-, 1-(1,1-dimethylethyl) ester; tert-Butyl N-[(tert-butoxy)carbonyl]-L-glutamyl-15-[(tert-butoxy)carbonyl]pentadecanoate; Protected Glutamic Acid C20 Ester; Boc-Glu(OtBu)-C20-ester
EINECS	Contact for details

Quality Control

Our L-Glutamic Acid derivative is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity, suitable for demanding research and cGMP manufacturing environments. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area %)	≥ 98.0%
Optical Rotation	[α]20/D: Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.