Description

2-(2,5-Difluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl[1,3,2]Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create novel herbicides, fungicides, and insecticides where the difluoro-methylphenyl moiety imparts enhanced biological activity and metabolic stability.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for electron-transport materials and emissive layer components in display and lighting technologies.
• Liquid Crystal & Polymer Chemistry: Incorporated into advanced monomers for creating high-performance polymers and liquid crystal displays with specific electronic and optical properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for constructing complex, polyfunctional aromatic and heteroaromatic systems.
• Material Science: Used in the development of organic semiconductors, photovoltaic materials, and other functional organic electronic materials.

Basic Information

Item	Details
Product Name	2-(2,5-Difluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl[1,3,2]Dioxaborolane
CAS No.	1116681-97-0
Molecular Formula	C13H17BF2O2
Molecular Weight	254.08 g/mol
Synonyms	2,5-Difluoro-4-methylbenzeneboronic acid pinacol ester; (2,5-Difluoro-4-methylphenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(2,5-difluoro-4-methylphenyl)-1,3,2-dioxaborolane; 2-(2,5-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2,5-Difluoro-4-methylphenyl)boronate; 2,5-Difluoro-4-methylphenylboronic acid pinacol ester; B-(2,5-Difluoro-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(2,5-Difluoro-4-Methylphenyl)-4,4,5,5-Tetramethyl[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and consistent performance in coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.