Description

2-Fluoro-5-Formylphenylboronic Acid Pinacol Ester is a high-value, multi-functional organoboron building block. This compound is essential for advanced organic synthesis, particularly in cross-coupling reactions like the Suzuki-Miyaura coupling, where it enables the precise introduction of a formyl-substituted fluorinated aromatic scaffold. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated aromatic rings and aldehyde handles for further derivatization.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the fluorine atom for metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Materials Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where the formyl group allows for polymerization or functional group interconversion.
• Chemical Biology & Probe Development: Useful for creating fluorescent probes, bioconjugation linkers, and other tools for biochemical research due to its reactive aldehyde functionality.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Fluoro-5-Formylphenylboronic Acid Pinacol Ester
CAS No.	1112208-82-8
Molecular Formula	C₁₃H₁₆BFO₃
Molecular Weight	250.08 g/mol
Synonyms	5-Formyl-2-fluorophenylboronic acid pinacol ester; (5-Formyl-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-5-formylbenzeneboronic acid pinacol ester; 2-Fluoro-5-formylphenyl-Bpin; 2-Fluoro-5-formylphenylboronic acid neopentyl glycol ester (common alternative); 2-Fluoro-5-formylbenzeneboronic acid MIDA ester (related protected form); PINACOL (2-FLUORO-5-FORMYLPHENYL)BORONATE
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Formylphenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive coupling reactions. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.