Description

2,2-Difluoro-2-(4-(Trifluoromethoxy)Phenyl)Acetic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethoxy and difluoroacetic acid functional groups, which are critical for modulating the physicochemical properties of target molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in CNS and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in electronic display technologies.
• Advanced Polymer Chemistry: Building block for specialty polymers requiring high thermal stability and chemical resistance.
• Organic Electronics: Intermediate in the synthesis of materials for OLEDs and other organic semiconductor applications.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorination methodologies and structure-activity relationships.

Basic Information

Product Name	2,2-Difluoro-2-(4-(Trifluoromethoxy)Phenyl)Acetic Acid
CAS No.	1112044-47-9
Molecular Formula	C9H5F5O3
Molecular Weight	256.13 g/mol
Synonyms	α,α-Difluoro-4-(trifluoromethoxy)phenylacetic Acid; 2,2-Difluoro-2-[4-(trifluoromethoxy)phenyl]acetic Acid; 4-(Trifluoromethoxy)benzoylfluoride, difluoroacetic acid derivative; [4-(Trifluoromethoxy)phenyl]difluoroacetic Acid; (4-Trifluoromethoxyphenyl)difluoroacetic Acid; Difluoro(4-trifluoromethoxyphenyl)acetic Acid; TFMP-DFA; CAS 1112044-47-9
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-(4-(Trifluoromethoxy)Phenyl)Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.