Description

Boronic Acid, B-(3-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-5-Yl)- is a high-value, fluorinated heterocyclic boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its primary commercial value lies in enabling the efficient construction of complex molecules through reliable cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients. The precise structure offers a strategic handle for introducing the 3-fluoro-1H-pyrrolo[2,3-b]pyridine moiety into target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Serves as a monomer or functionalization agent in the creation of advanced organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed as a handle for bioconjugation and the development of activity-based probes and covalent inhibitors.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations for custom synthesis and library production for client projects.
• Academic Research: Utilized in methodology development and synthetic chemistry studies within university and institutional laboratories.

Basic Information

Item	Details
Product Name	Boronic Acid, B-(3-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-5-Yl)-
CAS No.	1111637-69-4
Molecular Formula	C9H8BBrFN2O2
Molecular Weight	269.89 g/mol
Synonyms	(3-Fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid; 5-Borono-3-fluoro-1H-pyrrolo[2,3-b]pyridine; 3-Fluoro-1H-pyrrolo[2,3-b]pyridine-5-boronic acid; B-(3-Fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (pinacol ester precursor); 1111637-69-4; 3-Fluoro-1H-pyrrolo[2,3-b]pyridin-5-ylboronic acid
EINECS	Contact for details

Quality Control

Our Boronic Acid, B-(3-Fluoro-1H-Pyrrolo[2,3-B]Pyridin-5-Yl)- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting critical quality attributes. Our production adheres to cGMP guidelines where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and potentially light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.