Description

2,2-Difluoro-7-Oxa-Bicyclo[4.1.0]Heptane is a high-value, specialized bicyclic ether building block containing fluorine atoms. This compound is critical for medicinal chemistry and advanced materials research, where its unique strained-ring structure and fluorine substituents enable the synthesis of novel molecules with tailored properties. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated, strained-ring motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced, high-performance pesticides and herbicides where the fluorine atoms and oxa-bicyclic structure contribute to efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or other functional materials requiring specific stereochemistry and fluorination.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tools for studying biological systems and enzyme mechanisms.
• Catalyst & Ligand Development: Acts as a scaffold for creating novel chiral ligands or organocatalysts used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated bicyclic framework.

Basic Information

Product Name	2,2-Difluoro-7-Oxa-Bicyclo[4.1.0]Heptane
CAS No.	1109284-38-9
Molecular Formula	C6H8F2O
Molecular Weight	134.12 g/mol
Synonyms	2,2-Difluoro-7-oxabicyclo[4.1.0]heptane; 7-Oxa-2,2-difluorobicyclo[4.1.0]heptane; 2,2-Difluoro-7-oxanorbornane; Difluorinated oxa-norbornane; Oxa-bicycloheptane, 2,2-difluoro-; Bicyclo[4.1.0]heptane, 2,2-difluoro-7-oxa-
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-7-Oxa-Bicyclo[4.1.0]Heptane is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and synthesis. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC/NMR), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.