Description

o-Desmethyl Tramadol-D6 is a deuterium-labeled internal standard critical for accurate quantitative analysis in bioanalytical and forensic chemistry. This high-purity compound is essential for ensuring the precision and reliability of mass spectrometry-based assays, particularly for pharmacokinetic and metabolism studies. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology units requiring definitive quantification of tramadol and its metabolites.

Application

• Internal Standard for LC-MS/MS: Primary application as a deuterated internal standard for the precise quantification of O-desmethyltramadol (the active metabolite of tramadol) in biological matrices like plasma, serum, and urine.
• Pharmacokinetic & Bioavailability Studies: Enables accurate measurement of drug concentration-time profiles in clinical and pre-clinical research.
• Forensic Toxicology & Doping Control: Used in confirmatory testing for the presence of tramadol and its metabolites in forensic and anti-doping laboratories.
• Drug Metabolism and Disposition (DMPK): Facilitates studies on the metabolic pathways, clearance, and half-life of tramadol.
• Method Development & Validation: Serves as a critical component in developing and validating robust, regulatory-compliant analytical methods (e.g., following FDA/EMA guidelines).
• Reference Material for Quality Control: Acts as a certified reference material for calibrating instruments and verifying assay performance in quality control laboratories.

Basic Information

Item	Details
Product Name	o-Desmethyl Tramadol-D6
CAS No.	1109218-03-2
Molecular Formula	C15H19D6NO2
Molecular Weight	249.39 g/mol
Synonyms	O-Desmethyltramadol-d6; O-DSMT-d6; M1 Metabolite-d6 (Tramadol); 2-[(Dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol-d6; (+/-)-O-Desmethyltramadol-d6; Tramadol Metabolite M1-d6; Deuterated O-Desmethyl Tramadol
EINECS	Contact for details

Quality Control

Every batch of o-Desmethyl Tramadol-D6 is manufactured and analyzed under strict quality management systems to ensure the highest standards of identity, purity, and isotopic enrichment. Our products undergo rigorous testing, including advanced chromatographic and spectroscopic methods, to guarantee suitability for use as an internal standard in regulated environments. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), isotopic purity (by MS), and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, well-ventilated place. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.