Description

Tramadol-D6 Hcl is a deuterium-labeled internal standard of the centrally acting analgesic, tramadol hydrochloride. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is primarily utilized by pharmaceutical research and development laboratories, forensic toxicology units, and contract research organizations (CROs) for applications requiring high-precision measurement.

Application

• Pharmacokinetic and Bioanalytical Studies: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of tramadol and its metabolites in plasma, serum, and urine.
• Forensic Toxicology: Used in the confirmation and accurate measurement of tramadol levels in post-mortem and human performance testing, ensuring legally defensible results.
• Drug Metabolism and Disposition (DMPK) Research: Enables detailed studies on the absorption, distribution, metabolism, and excretion (ADME) profile of tramadol.
• Clinical Trial Support: Provides reliable data on drug concentration in patients during clinical trials for safety and efficacy evaluation.
• Method Development and Validation: Acts as a reference standard for developing, optimizing, and validating new analytical protocols in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and stability-indicating assays for tramadol hydrochloride drug substances and products.

Basic Information

Item	Detail
Product Name	Tramadol-D6 Hcl
CAS No.	1109217-84-6
Molecular Formula	C16H19D6ClNO2 • HCl
Molecular Weight	328.89 g/mol (for monoisotopic)
Synonyms	Tramadol-d6 Hydrochloride; (1R,2R)-2-[(Dimethyl-d6)amino]methyl-1-(3-methoxyphenyl)cyclohexanol Hydrochloride; Tramadol (phenyl-d5, N-methyl-d) Hydrochloride; Tramadol-d6 HCl; Deuterated Tramadol HCl; Tramadol Internal Standard; UNII-39J1LGJ30J (base); (±)-trans-Tramadol-d6 Hydrochloride
EINECS	Contact for details

Quality Control

Our Tramadol-D6 Hcl is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for identity, assay, isotopic enrichment, and purity by HPLC. We support compliance with GMP/GLP principles for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Enrichment	≥98.0 atom % D
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.