Description

(R,S)-Ambrisentan-Acyl-β-D-Glucuronide Min. 95% is a high-purity metabolite reference standard of the pulmonary arterial hypertension drug, Ambrisentan. This compound is essential for pharmaceutical research and development, specifically for conducting metabolism studies, pharmacokinetic analysis, and bioanalytical method validation. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and regulatory compliance activities.

Application

• Pharmacokinetic and Metabolism Studies: Used as a reference standard to identify and quantify the acyl glucuronide metabolite of Ambrisentan in biological matrices.
• Bioanalytical Method Development & Validation (FDA/EMA): Critical for developing and validating robust LC-MS/MS or HPLC methods for drug monitoring.
• Drug Impurity Profiling: Serves as a known impurity or degradation product standard for quality control of Ambrisentan active pharmaceutical ingredient (API) and finished dosage forms.
• Toxicology and Safety Assessment: Employed in studies to understand the safety profile and potential reactivity of the acyl glucuronide metabolite.
• Stability Indicating Methods: Used to assess the stability of Ambrisentan under various conditions by tracking its metabolite formation.
• Clinical Research: Supports clinical trials by enabling accurate measurement of metabolite levels in patient samples.

Basic Information

Product Name	(R,S)-Ambrisentan-Acyl-β-D-Glucuronide Min. 95%
CAS No.	1106685-82-8
Molecular Formula	C32H34N2O11
Molecular Weight	622.62 g/mol
Synonyms	Ambrisentan Acyl Glucuronide; Ambrisentan Glucuronide; (R,S)-Ambrisentan β-D-Glucuronide; Letairis Metabolite; Volibris Metabolite; 2-[[4,6-Dimethyl-2-[2-(4-methyl-6-oxo-5-propyl-1H-pyrimidin-2-yl)phenoxy]pyrimidin-5-yl]oxy]acetic acid β-D-Glucopyranosiduronic acid; 1-(β-D-Glucopyranuronosyl)-2-[[4,6-dimethyl-2-[2-(4-methyl-6-oxo-5-propyl-1H-pyrimidin-2-yl)phenoxy]pyrimidin-5-yl]oxy]ethanone
EINECS	Contact for details

Quality Control

Every batch of our (R,S)-Ambrisentan-Acyl-β-D-Glucuronide is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) are supplied with each shipment, detailing purity (HPLC), identity confirmation (NMR, MS), and impurity profiles. Our quality commitment ensures consistency and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	Min. 95.0%
Water Content (KF)	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.